Convulsions associated with cyclosporin A in renal transplant recipients.

Cyclosporin A has proved to be a valuable drug both in the prevention of graft rejection after solid organ transplantation' and in the prevention of graft versus host disease after bone marrow transplantation.2 Caine et al treated the first cadaver renal allograft recipients with cyclosporin A in 1978,3 and toxicity due to the drug was noted soon afterwards. The adverse effects in transplant recipients attributed to cyclosporin are numerous, with renal and hepatic toxicity and tremor being well described. We report three cases of neurotoxicity presenting with grand mal seizures in renal transplant recipients which we believe to have been associated with cyclosporin A.